The use of oxygen as a possible screening biomarker for the diagnosis of chronic fatigue

The aim of this study was to verify whether the mean percentage oxygen use in aerobic-anaerobic transition phase or isocapnic buffering (IB) lower women with chronic fatigue syndrome (CFS) compared healthy women, and if variable could be used as a screening biomarker for diagnosis CFS A cross-sectional conducted. Forty-four adult (22 22 healthy) performed cycle ergometer stress test gas analyser (CPET). Maximum consumption (V˙O2 max), at anaerobic threshold Vt2), maximum ventilatory volume (V˙E time maintenance (IB duration), (% O2 IB) were analyzed. Data explored from principal component analysis. Groups matched by propensity score mismatched BMI comparison means medians performed. logistic regression model built predict probability CFS. median values variables obtained CPET significantly higher group In model, VO2 max, IB duration, % selected predictors. sensitivity specificity greater than 90%. combination factors V˙O2 can